GSK2982772
Huahana Huahana
Huahana Huahana
| Nui Puke | Loaʻa | Kumukuai (USD) |
| 100mg | Loaʻa | 500 |
| 500mg | Loaʻa | 800 |
| 1g | Loaʻa | 1200 |
| Nui hou aku | E kiʻi i nā huaʻōlelo | E kiʻi i nā huaʻōlelo |
Inoa Kimia:
(S)-5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b]-[1,4]oxazepin-3-yl)-4H-1,2, 4-triazole-3-carboxamide
SMILES Code:
O=C(C1=NN=C(CC2=CC=CC=C2)N1)N[C@@H]3C(N(C)C4=CC=CC=C4OC3)=O
Code InChi:
InChI=1S/C20H19N5O3/c1-25-15-9-5-6-10-16(15)28-12-14(20(25)27)21-19(26)18-22-17(23- 24-18)11-13-7-3-2-4-8-13/h2-10,14H,11-12H2,1H3,(H,21,26)(H,22,23,24)/t14 -/m0/s1
Ki InChi:
LYPAFUINURXJSG-AWEZNQCLSA-N
huaʻōlelo:
GSK-2982772, GSK 2982772, GSK2982772, 1622848-92-3
Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO
Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).
wehewehe:
ʻO GSK2982772 kahi mea hoʻokipa ikaika a koho i ka Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate no ka mālama ʻana i nā maʻi ʻeha. ʻO GSK2982772, aia i kēia manawa ma ka pae 2a nā haʻawina hauʻoli no psoriasis, rheumatoid arthritis, a me ulcerative colitis. Hoʻopaʻa ikaika ʻo GSK2982772 iā RIP1 me kahi kikoʻī kinase nani a he hana maikaʻi loa i ka pale ʻana i nā pane kelepona pili i ka TNF. Ua puka mai ʻo RIP1 ma ke ʻano he kinase upstream koʻikoʻi i hōʻike ʻia e hoʻoponopono i ka mumū ma o nā scaffolding a me nā hana kikoʻī kinase.
Kuhikuhi: RIP1
