GDC-0077

Inoa Kimia:

(S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4 ]oxazepin-9-yl)amino)propanamide

SMILES Code:

C[C@@H](C(N)=O)NC1=CC=C(C2=NC(N3[C@H](C(F)F)COC3=O)=CN2CCO4)C4=C1

Code InChi:

InChI=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11) 24)25-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21 ,26)/t9-,12-/m0/s1

Ki InChi:

SGEUNORSOZVTOL-CABZTGLSA-N

Hua'ōlelo:

GDC-0077, GDC0077, GDC 0077, 2060571-02-8

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

ʻO GDC-0077 kahi mea hoʻopaneʻe PI3K i loaʻa i ka waha a koho ʻia (IC50 = 0.038 + 0.003 nM) me ka koho koho 300-fold ma luna o nā isoforms Class I PI3K. Hoʻohana ʻo GDC-0077 i kāna hana ma ka hoʻopaʻa ʻana i ka pūnaewele hoʻopaʻa ATP o PI3K, no laila ke kāohi nei i ka phosphorylation o PIP2 i PIP3.

Pahuhopu: PI3K