BAZ2-ICR

Inoa Kimia:

4-(4-(1-methyl-1H-pyrazol-4-yl)-1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-imidazol-5-yl)benzonitrile

SMILES Code:

CN(N=C1)C=C1C2=C(C3=CC=C(C#N)C=C3)N(CCC4=CN(C)N=C4)C=N2

Code InChi:

InChI=1S/C20H19N7/c1-25-12-16(10-23-25)7-8-27-14-22-19(18-11-24 -26(2)13-18)20(27)17-5-3-15(9-21)4-6-17/h3-6,10-14H,7-8H2,1-2H3

Ki InChi:

RRZVGDGTWNQAPW-UHFFFAOYSA-N

Hua'ōlelo:

BAZ2-ICR, BAZ2ICR, BAZ2 ICR, 1665195-94-7

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

ʻO BAZ2-ICR kahi noiʻi kemika maikaʻi loa no nā haʻawina hana o nā BAZ2 bromodomains in vitro a i vivo. ʻO ka bromodomain i loaʻa nā protein BAZ2A/B i nā kuleana koʻikoʻi i ka hoʻoponopono hou ʻana o chromatin a me ka hoʻoponopono ʻana i nā RNA noncoding. Loaʻa iā BAZ2-ICR ka IC50 (BAZ2A) = 130 nM; IC50(BAZ2B) = 180 nM; logD = 1.05; solubility 25 mM (D2O) a me F = 70%.

Pahuhopu: BAZ2