GLPG0187

Sunan Sinadari:

(S) -3-((2,5-dimethyl-6--4- (5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl) piperidin-1-yl) pyrimidin-4- yl)amino)-2-((4-methoxyphenyl)sulfonamido)propanoic acid

Lambar SMILES:

O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC= C(OC)C=C5)=O

Lambar InChi:

InChi=1S/C29H37N7O5S/c1-18-26(31-17-25(29(37)38)35-42(39,40)23-9-7-22(41-3)8-10-23) 32-19 (2) 33-28 (18) 36-15-12-20 (13) -16-36)24-11-6-21-5-4-14-30-27(21)34-24/h6-11,20,25,35H,4-5,12-17H2,1-3H3 ,(H,30,34)(H,37,38)(H,31,32,33)/t25-/m0/s1

InChi Key:

CXHCNOMGODVIKB-VWLOTQADSA-N

Mabuɗin kalma:

GLPG0187, GLPG-0187, GLPG 0187, 1320346-97-1

Solubility:Mai narkewa a cikin DMSO

Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).

Bayani:

A cikin ƙayyadaddun ƙayyadaddun lokaci, GLPG0187 yana nuna zaɓi don yawancin masu karɓar integrin na RGD tare da IC50s na 1.3, 3.7, 2.0, 1.4, 1.2, 7.7 nM don αvβ1, αvβ3, αvβ5, αvβ,6, da αvβ8 GLPG0187 shine mai hanawa mai ƙarfi na resorption na osteoclastic da angiogenesis. Jiyya tare da GLPG0187 kashi-dogara yana ƙara ƙimar E-cadherin/vimentin, yana mai da sel ƙarin epithelial, sessile phenotype. GLPG0187 kashi-dogara yana rage girman aldehyde dehydrogenase babban yawan yawan ƙwayoyin cutar kansar prostate[1]. GLPG0187 jiyya yana haifar da zagaye tantanin halitta da kumbura. GLPG0187 yana nuna raguwa mai mahimmanci na dogaro da kashi a ƙaurawar ƙwayar ƙwayar cuta. GLPG0187 a duk abubuwan tattarawa yana rage haɓakar tantanin halitta [2].

manufa: αvβ1