Saukewa: RGX-104
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 100mg | A Stock | 500 |
| 500mg | A Stock | 800 |
| 1g | A Stock | 1200 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
(R) -2-[3-[3-[2-Chloro-3- (trifluoromethyl) benzyl] (2,2-diphenylethyl) amino]-3-methylpropoxy] phenyl] acetic acid hydrochloride.
Lambar SMILES:
O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4 = CC=CC=C4)C)=C1.[H]Cl
Lambar InChi:
InChi=1S/C34H33ClF3NO3.ClH/c1-24(18-19-42-29-16-8-10-25(20-29)21-32(40)41)39(22-28-15-9- 17-31 (33 (28)35)34 (36,37)38)23-30 (26-11-4-2-5-12-26)27-13-6-3-7-14-27; /h2-17,20,24,30H,18-19,21-23H2,1H3,(H,40,41);1H/t24-;/m1./s1
InChi Key:
LCMIYQOJZLRHTO-GJFSDDNBSA-N
Mabuɗin kalma:
RGX-104 HCL, RGX-104, RGX104, RGX 104, 610318-03-1
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).
Bayani:
RGX-104 shine hanta X mai karɓar beta agonist tare da yuwuwar immunomodulating da ayyukan antineoplastic. Bayan gudanar da baki, RGX-104 yana zaɓaɓɓun hari kuma yana ɗaure zuwa LXRbeta, ta haka yana kunna siginar tsaka-tsaki na LXRbeta, wanda ke haifar da kwafin wasu ƙwayoyin cuta masu hana ƙari da raguwar wasu ƙwayoyin cuta masu haɓaka ƙari. Wannan musamman yana kunna bayanin apolipoprotein E (ApoE), furotin mai hana ƙari, a cikin ƙwayoyin tumo da wasu ƙwayoyin rigakafi. Wannan yana kunna tsarin rigakafi na asali, wanda ya haifar da raguwar ƙwayoyin cuta na myeloid-derived suppressor (MDSCs), ƙwayoyin tumo da ƙwayoyin endothelial a cikin ƙananan ƙwayoyin cuta. Wannan yana jujjuya gujewa na rigakafi, yana haɓaka martanin rigakafin ƙwayar cuta kuma yana hana yaduwar ƙwayoyin ƙari.
manufa: LXRbeta
