Saukewa: PQR530
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 100mg | A Stock | 500 |
| 500mg | A Stock | 800 |
| 1g | A Stock | 1200 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
(S) -4- (difluoromethyl) -5- (4- (3-methylmorpholino) -6-morpholino-1,3,5-triazin-2-yl) pyridin-2-amine
Lambar SMILES:
NC1=NC=C(C2=NC(N3[C@@H](C)COCC3=NC(N4CCOCC4)=N2)C(C(F)F)=C1
Lambar InChi:
InChi=1S/C18H23F2N7O2/c1-11-10-29-7-4-27(11)18-24-16(13-9-22-14(21)8-12(13)15(19)20) 23-17 (25-18)26-2-5-28-6-3-26/h8-9,11,15H,2-7,10H2,1H3,(H2,21,22)/t11-/m0 /s1
InChi Key:
SYKBZXMKAPICSO-NSHDSACASA-N
Mabuɗin kalma:
PQR530, PQR-530, PQR 530, 1927857-61-1
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).
Bayani:
PQR530 shine mai hanawa pan-PI3K/mTORC1/2 mai ƙarfi sosai. PQR530 ya hana furotin kinase B (PKB, pSer473) da furotin ribosomal S6 (pS6, pSer235/236) phosphorylation tare da ƙimar IC50 na 0.07 µM. PQR530 ya nuna kyakkyawan zaɓi a kan faffadan kinases, da kuma kyakkyawan zaɓin zaɓi tare da enzymes masu karɓa marasa alaƙa da tashoshi ion. Bugu da ƙari, PQR530 ya nuna ƙarfi a cikin wani panel na 44 ciwon daji Lines (NTRC Oncolines TM) don hana ciwon daji girma cell (ma'ana darajar ga GI50 na 426 nM). Aikace-aikacen baka na PQR530 zuwa beraye ya haifar da daidaitaccen kashi na PK kuma ya nuna kyakkyawan yanayin rayuwa na baka da kyakkyawar shigar kwakwalwa.
manufa: PI3K/mTOR
