Vactosertib

Sunan Sinadari:

N- ((4- ([1,2,4]triazolo [1,5-a] pyridin-6-yl) -5- (6-methylpyridin-2-yl) -1H-imidazol-2-yl) methyl -2-fluoroaniline

Lambar SMILES:

FC1=CC=CC=C1NCC2=NC(C3=CN4C(C=C3)=NC=N4)=C(C5=NC(C)=CC=C5)N2

Lambar InChi:

InChi=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12-15)28- 19 (29-22) 11-24-17-7-3-2-6-16 (17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29)

InChi Key:

FJCDSQATIJKQKA-UHFFFAOYSA-N

Mabuɗin kalma:

Vactosertib, EW-7197, EW7197, EW 7197, 1352608-82-2

Solubility:Mai narkewa a cikin DMSO

Ajiya:0 - 4 ° C na gajeren lokaci (kwanaki zuwa makonni), ko -20 ° C na dogon lokaci (watanni)

Bayani:

Vactosertib, wanda kuma aka sani da EW-7197 shine mai hanawa ALK5 mai ƙarfi. EW-7197 ya nuna ƙarfin aiki a cikin vivo anti-metastatic aiki, yana nuna yiwuwar amfani da shi azaman maganin ciwon daji. EW-7197 yana hana siginar TGF-β/Smad. EW-7197 yana kawar da ƙaurawar ƙwayar ƙwayar cuta ta TGF-β1 da mamayewa. EW-7197 yana hana metastasis na ciwon nono zuwa huhu.EW-7197 yana tsawaita rayuwar BALB/c 4T1 mice ta hanyar hana EMT. EW-7197 yana hana metastasis kuma yana haɓaka ayyukan cytotoxic T lymphocytes (CTLs) a cikin 4T1 orthotopic grafted mice.

manufa: ALK