ND-630
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 10mg | A hannun jari | 300 |
| 50mg | A hannun jari | 500 |
| 100mg | A hannun jari | 800 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
(R) -2- (1- (2--methoxyphenyl) -2- ((tetrahydro-2H-pyran-4-yl) oxy) ethyl -5-methyl-6- (oxazol-2-yl) -2,4-dioxo-1,2-dihydrothieno[2,3-d] pyrimidin-3(4H) -yl -2-methylpropanamide
Lambar SMILES:
O=C(N)C(C)(C)N(C(N(C[C@@H])(C1=CC=CC=C1OC)OC2CCOCC2)C3=C4C(C)=C(C5=NC= CO5)S3)=O)C4=O
Lambar InChi:
InChi=1S/C28H31N3O8S/c1-16-21-24(32)31(28(2,3)26(33)34)27(35)30(25(21)40-22(16)23-29- 11-14-38-23)15-20 (39-17-9-12-37-13-10-17)18-7-5-6-8-19 (18)36-4/h5-8, 11,14,17,20H,9-10,12-13,15H2,1-4H3,(H,33,34)/t20-/m0/s1
InChi Key:
ZZWWXIBKLBMSCS-FQEVSTJZSA-N
Mabuɗin kalma:
ND-630, ND630, ND 630, GS-0976, GS0976, GS 0976, NDI-010976, NDI010976, NDI 010976, Firsocostat, 1434635-54-7
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).
Bayani:
ND-630 yana hana hACC1 (IC50 = 2.1 ± 0.2 nM) da hACC2 (IC50 = 6.1 ± 0.8 nM). Hani abu ne mai jujjuyawa kuma musamman musamman ga ACC. ND-630 yana hana ayyukan ACC ta hanyar hulɗa a cikin phosphopeptide-acceptor da dimerization site na enzyme don hana dimerization. ND-630 yana hana haɓakar fatty acid tare da EC50 na 66 nM a cikin ƙwayoyin HepG2 ba tare da canza jimlar adadin tantanin halitta ba, haɓakar furotin na salula, da haɗar acetate cikin cholesterol[1].
manufa: ACC
