BLU-285
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 1g | A hannun jari | 900 |
| 5g | A hannun jari | 3600 |
| 10 g | A hannun jari | 6200 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
(S) -1- (4-fluorophenyl) -1- (2- (4---6- (1-methyl-1H-pyrazol-4-yl) pyrrolo [2,1-f] [1,2,4] ]triazin-4-yl) piperazin-1-yl) pyrimidin-5-yl) ethan-1-amin
Lambar SMILES:
CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@@])(C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC= N3)=C2)=C1
Lambar InChi:
InChi=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35( 8-10-36)24-23-11-18 (16-37 (23)33-17-31-24) 19-12-32-34 (2) 15-19/h3-6,11-17H, 7-10,28H2,1-2H3/t26-/m0/s1
InChi Key:
DWYRIWUZIJHQKQ-SANMLTNESA-N
Mabuɗin kalma:
BLU-285, BLU 285, BLU285, Avapritinib
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).
Bayani:
Avapritinib (BLU-285) ya nuna aikin biochemical in vitro akan KIT exon 17 mutant enzyme, KIT D816V (IC50=0.27 nM). Ayyukan salula na Avapritinib akan ƙwayoyin cuta na KIT D816 ana auna su ta hanyar autophosphorylation a cikin layin kwayar cutar sankarar jini ta mutum HMC1.2, da layin mastocytoma na linzamin kwamfuta na P815 tare da IC50 = 4 da 22 nM, bi da bi. A cikin sel Kasumi-1, a (8;21) - ingantaccen layin salula na AML tare da maye gurbin KIT exon 17 N822K, Avapritinib da ƙarfi yana hana KIT N822K mutant autophosphorylation (IC50 = 40 nM), siginar ƙasa, da haɓakar salula (IC50= 75 nM)[1].
manufa: KIT
