BLU-9931
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 100mg | A hannun jari | 220 |
| 300mg | A hannun jari | 500 |
| 1g | A hannun jari | 1350 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
N- (2- (6- (2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino) -3-methylphenyl) acrylamide.
Lambar SMILES:
C=CC(NC1=CC=CC(C)=C1NC2=NC=C3C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C=CC3=N2)=O
Lambar InChi:
InChi=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10-) 17(16)31-26)22-23(27)19(34-3)12-20(35-4)24(22)28/h5-13H,1H2,2-4H3,(H,30,33 (H,29,31,32)
InChi Key:
TXEBNKKOLVBTFK-UHFFFAOYSA-N
Mabuɗin kalma:
BLU-9931, BLU9931, BLU 9931, 1538604-68-0
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).
Bayani:
A cikin ƙwayoyin MDA-MB-453, BLU9931 da ƙarfi yana hana phosphorylation na hanyar siginar FGFR4. BLU9931 yana hana yaduwar layin salula na HCC wanda ke bayyana madaidaicin siginar FGFR4, kamar su Hep 3B, HUH-7, da layin salula na JHH-7, tare da EC50 na<1 μM. BLU9931 kuma yana hana haɓakawa a cikin layin salula da aka samo daga PDX tare da ingantacciyar hanyar siginar FGFR4[1]. BLU9931 yana haifar da raguwar ƙwayar ƙwayar cuta a cikin nau'in ciwon daji na hanta wanda ke bayyana hadaddun ligand / mai karɓa mai aiki wanda ya ƙunshi FGF19 / FGFR4 / KLB kuma yana ƙara zuwa jerin girma na wakilai na anti-FGFR4 [2].
Saukewa: FGFR4
