Osimertinib Mesylate

Sunan Sinadari:

N- (2- (2- (dimethylamino) ethyl) (methyl) amino) -4-methoxy-5-((4- (1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino phenyl) acrylamide mesylate

Lambar SMILES:

CN(CCN(C)C)C1=CC(OC)=C(C=C1NC(C=C)=O)NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2 .OS(=O)(C)=O

Lambar InChi:

InChi=1S/C28H33N7O2.CH4O3S/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3) 32-28-29-13-12-21 (31-28)20-18-35 (5)24-11-9-8-10-19 (20)24;1-5(2,3)4/ h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32);1H3,(H,2,3,4)

InChi Key:

FUKSNUHSJBTCFJ-UHFFFAOYSA-N

Mabuɗin kalma:

AZD-9291, AZD9291, AZD 9291, Tagrisso, Osimertinib Mesylate, 1421373-66-1

Solubility:Mai narkewa a cikin DMSO

Ajiya:0 - 4 ° C na gajeren lokaci (kwanaki zuwa makonni), ko -20 ° C na dogon lokaci (watanni)

Bayani:

Osimertinib, wanda kuma aka sani da mereletinib da AZD-9291, shine mai hanawa na EGFR na ƙarni na uku, ya nuna alƙawarin a cikin binciken da ya dace kuma yana ba da bege ga marasa lafiya da ciwon huhu na huhu waɗanda suka zama masu tsayayya ga masu hana EGFR na yanzu. AZD9291 yana aiki sosai a cikin ƙirar ƙira kuma ana jure shi sosai a cikin ƙirar dabba. Yana hana duka kunnawa da juriya na maye gurbi na EGFR yayin da yake kiyaye nau'in EGFR na yau da kullun wanda ke cikin fata na al'ada da ƙwayoyin hanji, don haka rage illolin da aka fuskanta tare da magunguna a halin yanzu. An amince da Osimertinib a ranar Nuwamba 2015.

Saukewa: EGFR