Bayani na EED226
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 25mg ku | A hannun jari | 300 |
| 50mg | A hannun jari | 500 |
| 100mg | A hannun jari | 800 |
Sunan Sinadari:
N (furan-2-ylmethyl) -8- (4- (methylsulfonyl) phenyl)-[1,2,4]triazolo [4,3-c] pyrimidin-5-amine
Lambar SMILES:
O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O
Lambar InChi:
InChi=1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-11-20-21-16(15)22) 18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19)
InChi Key:
DYIRNMPIZZNBK-UHFFFAOYSA-N
Mabuɗin kalma:
EED226, EED-226, EED 226, 2083627-02-3
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).
Bayani:
EED226 mai ƙarfi ne mai ƙarfi, mai inganci kuma mai zaɓin mai hanawa na EZH2 da EZH1 da aka ƙididdige su akan kewayon kewayon epigenetic da waɗanda ba na asali ba. Yana da ƙarfi yana rage alamar H3K27Me3 na duniya a cikin sel kuma yana nuna zaɓin tasirin kashe tantanin halitta a cikin sel ɗauke da maye gurbin heterozygous Y641N. EED226 yana da matsakaicin matsakaici kamar yadda aka auna a cikin sel Caco-2 a A → B = 3.0x10-6 cm / s, tare da rabo na efflux a 7.6[1].
Saukewa: EED226
