Bardoxolone methyl
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 1g | A Stock | 300 |
| 5g | A Stock | 1200 |
| 10 g | A Stock | 2000 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
(4aS,6aR,6bS,8aR,12aS,14aR,14bS) -methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4 ,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate
Lambar SMILES:
O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4 (C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC
Lambar InChi:
InChi=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15- 23-29 (5) 16-19 (18-33)25 (35)28 (3,4)22 (29)9-10-30 (23,31)6/h15-16,20,22,24H, 9-14,17H2,1-8H3/t20-,22?,24+,29+,30-,31-,32+/m1/s1
InChi Key:
WPTTVJLTNAWYAO-OROHISIGSA-N
Mabuɗin kalma:
Bardoxolone methyl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, methyl CDDO, CDDO methyl ester, 218600-53-4
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4 ° C na gajeren lokaci (kwanaki zuwa makonni), ko -20 ° C na dogon lokaci (watanni)
Bayani:
CDDO mai suna oleanane triterpenoid (Abu na 81035) shine mai kunnawa Nrf2 wanda ke hana haɓakawa kuma yana haifar da bambance-bambance da apoptosis a cikin ƙwayoyin kansa daban-daban. C-28 methyl ester na CDDO (CDDO methyl ester) yana toshe haɗin wayar salula na inducible nitric oxide synthase (iNOS) da COX-2 mai inducible a cikin macrophages linzamin kwamfuta na INF-γ tare da ƙimar IC50 na 0.11 nM. Yana haifar da apoptosis, yana haifar da bambance-bambance, kuma yana hana amsawar kumburi a cikin ƙwayoyin ƙwayar cuta daban-daban ta hanyar hana siginar IκBα kinase / NF-κB. CDDO methyl ester yana da aikin antidiabetic mai ƙarfi, yana rage maganganun cytokine na proinflammatory a cikin nau'in nau'in ciwon sukari na nau'in 2 masu ciwon sukari mai girma da kuma a cikin Leprdb / db mice da kuma haifar da furotin da aka kunna AMP da kunna LKB1 a cikin tsoka da hanta.
Saukewa: NF-kB
