Batefeenterol

Sunan Sinadari:

"(R)-1-(3-(2-chloro-4-((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl) ethyl)amino) methyl -5-methoxyphenyl) amino -3-oxopropyl) piperidin-4-yl [1,1'-biphenyl] -2-ylcarbamate Batefenterol Succinate"

Lambar SMILES:

O=C(OC1CCN(CCC(NC2=CC(OC)=C(CNC[C@H](O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)= O)CC1)NC5=CC=CC=C5C6=CC=CC=C6

Lambar InChi:

InChi=1S/C40H42ClN5O7/c1-52-36-22-33(31(41)21-26(36)23-42-24-35(48)29-11-13-34(47)39-30( 29) 12-14-37 (49) 45-39) 43-38 (50) 17-20-46-18-15-27 (16-19-46) 53-40 (51) 44-32-10- 6-5-9-28(32)25-7-3-2-4-8-25/h2-14,21-22,27,35,42,47-48H,15-20,23-24H2, 1H3,(H,43,50)(H,44,51)(H,45,49)/t35-/m0/s1

InChi Key:

URWYQGVSPQJGGB-DHUJRADRSA-N

Mabuɗin kalma:

Batefenterol, TD-5959, GSK961081, 743461-65-6, GSK-961081, GSK 961081, TD5959, TD 5959, 743461-65-6

Solubility:Mai narkewa a cikin DMSO

Ajiya:0 - 4 ° C na gajeren lokaci (kwanaki zuwa makonni), ko -20 ° C na dogon lokaci (watanni)

Bayani:

Batefenterol shine antagonist na muscarinic da β2-adrenergic agonist (β2-AR) agonist (Kis = 1.4, 1.3, da 3.7 nM, don hM2, hM3, da hβ2-AR, bi da bi a cikin gwajin dauri na radioligand). Batefenterol yana nuna aikin hβ2-AR agonist mai ƙarfi (EC50 = 0.29 nM) tare da zaɓin aiki na 440- da 320 akan hβ1- da hβ3-ARs, bi da bi. nama kuma yana hana amsawar bronchoconstrictor a cikin gwajin rigakafin bronchoprotection na alade (ED50 = 6.4 µg/mL). Shirye-shiryen da ke ɗauke da batefenterol suna cikin gwaje-gwajen asibiti don magance cututtukan cututtukan huhu na yau da kullun (COPD).

Manufa: β2-adrenoceptor