LX-2761
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 100mg | A Stock | 500 |
| 500mg | A Stock | 800 |
| 1g | A Stock | 1200 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
N- (1- ((2- (Dimethylamino) ethyl)amino) -2-methyl-1-oxopropan-2-yl) -4- (2-methyl-5-(2S,3R,4R, 5S,6R) -3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl) benzyl) phenyl) -butanamide
Lambar SMILES:
O=C(NC(C)(C)C(NCCN(C)C)=O)CCCC1=CC=C(CC2=CC([C@H]3[C@H](O)[C@@ H](O)[C@H](O)[C@@H](SC)O3=CC=C2C)C=C1
Lambar InChi:
InChi=1S/C32H47N3O6S/c1-20-10-15-23(29-27(38)26(37)28(39)30(41-29)42-6)19-24(20)18-22- 13-11-21 (12-14-22) 8-7-9-25 (36)34-32 (2,3)31 (40) 33-16-17-35 (4) 5/h10-15, 19,26-30,37-39H,7-9,16-18H2,1-6H3,(H,33,40)(H,34,36)/t26-,27-,28+,29+,30 -/m1/s1
InChi Key:
BNPZTRDIESRGTC-IXYVTWBDSA-N
Mabuɗin kalma:
LX-2761, LX2761, LX 2761, 1610954-97-6
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).
Bayani:
LX2761 mai hanawa SGLT1 ne na gida wanda ke da ƙarfi sosai a cikin vitro kuma yana jinkirta sha glucose na hanji a cikin vivo don haɓaka sarrafa glycemic. LX2761 yana da hSGLt1 2.2 nM; hSGLT2 2.7 nM da F% =<2. LX2761 yana da ƙarfi sosai, ingantaccen sinadari, kuma ƙarancin ƙarancin ƙwayar cuta wanda ya sami tabbacin ra'ayi a cikin OGTT a ƙananan allurai. An tsara LX2761 don kasancewa a cikin hanji bayan bayarwa na baki don hana SGLT1 a cikin gida ba tare da rinjayar tsarin SGLT1 / 2 a cikin koda ba.
Saukewa: SGLT1
