GSK2256098

Sunan Sinadari:

2-((5-chloro-2-((1-isopropyl-3-methyl-1H-pyrazol-5-yl)amino)pyridin-4-yl)amino)-N-methoxybenzamide

Lambar SMILES:

CC1=NN(C(=C1)NC2=NC=C(C(=C2)NC3=CC=CC=C3C(=O)NOC)Cl)C(C)C

Lambar InChi:

InChi=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22 -18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23 ,24)

InChi Key:

BVAHPPKGOOJSPU-UHFFFAOYSA-N

Mabuɗin kalma:

GSK2256098, GSK-2256098, GSK 2256098, GTPL7939, GTPL 7939, GTPL-7939, 1224887-10-8

Solubility:Mai narkewa a cikin DMSO

Ajiya:0 - 4°C na gajeren lokaci (kwanaki zuwa makonni), ko -20°C na dogon lokaci (watanni).

Bayani:

GSK2256098, wanda kuma aka sani da GTPL7939, shine mai hanawa adhesion kinase-1 (FAK) tare da yuwuwar ayyukan antiangiogenic da antineoplastic. Mai hana FAK GSK2256098 yana hana FAK, wanda zai iya hana ƙaddamar da tsaka-tsakin tsaka-tsaki na hanyoyin watsa siginar da yawa na ƙasa, gami da ERK, JNK/MAPK da PI3K/Akt, don haka yana hana ƙaurawar ƙwayar ƙwayar cuta, haɓakawa da rayuwa, da ƙari angiogenesis. Ana kunna tyrosine kinase FAK ta al'ada ta hanyar ɗaure zuwa integrins a cikin matrix na extracellular (ECM) amma ana iya haɓakawa kuma ana kunna shi gaba ɗaya a cikin nau'ikan ƙwayoyin ƙari daban-daban.

manufa: FAK