NTN21277

Ainm Ceimigeach:

(2S,4R)-1-(S)-2-(3-(2-(5-(4-(3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl) oxy) pentyl) oxy) ethoxy) propanamido) -3,3-dimethylbutanoyl)-4-hydroxy-N- (4- (4-methylthiazol-5-yl) benzyl) pyrrolidine-2-carboxamide

Còd SMILES:

O=C([C@H]1N(C([C@@H)(NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC) )=O) C(C)(C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

Còd InChi:

InChI=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-33(57) 26-56(38)46(60)43(47(2,3)4)55-41(58)15-18-63-20-19-62-16-7-6-8-17-64- 40-23-34-37(24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32/h9- 14,21,23-24,27-28,33,38,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55, 58)(H,51,52,54)/t33-,38+,43-/m1/s1

iuchair InChi:

NICKHWYZMNLEPJ-TZSMONEZSA-N

Facal-luirg:

PROTAC 3 stèidhichte air Gefitinib; NTN21277; NTN-21277; TN 21277

Solubility: 

Stòradh: 

Tuairisgeul:

Tha NTN21277, ris an canar cuideachd PROTAC 3 stèidhichte air Gefitinib na PROTAC a tha a’ fastadh VHL a dh’ adhbharaicheas crìonadh mutants EGFR agus EGFR le DC50 de 11.7 nM agus 22.3 nM airson cealla HCC827 (Exon 19 del) agus cealla H3258R (L).

Targaid: EGFR