CB-839

Ainm Ceimigeach:

2-(pyridin-2-yl)-N-(5-(4-(6-(2-(3-(trifluoromethoxy)phenyl)acetamido)pyridazin-3-yl)butyl)-1,3,4-thiadiazol -2-il) acetamide

Còd SMILES:

O=C(NC1=CC=C(CCCCC2=NN=C(NC(CC3=NC=CC=C3)=O)S2)N=N1)CC4=CC(OC(F)(F)F)=CC =C4

Còd InChi:

InChI=1S/C26H24F3N7O3S/c27-26(28,29)39-20-9-5-6-17(14-20)15-22(37)31-21-12-11-18(33-34- 21) 7-1-2-10-24- 35-36-25(40-24)32-23(38)16-19-8-3-4-13-30-19/h3-6,8-9,11-14H,1-2,7, 10,15-16H2,(H,31,34,37)(H,32,36,38)

iuchair InChi:

PRAAPINBUWJLGA-UHFFAOYSA-N

Facal-luirg:

CB-839, CB839, CB 839, 1439399-58-2

Solubility:Soluble ann an DMSO

Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan).

Tuairisgeul:

“Tha CB-839 na neach-dìon beòil bith-ruigsinneach de glutaminase, le gnìomhachd antineoplastic a dh’ fhaodadh a bhith ann. Air rianachd beòil, tha CB-839 gu roghnach agus gu neo-ghluasadach a’ bacadh glutaminase, einnsein mitochondrial a tha riatanach airson an aminoidid glutamine a thionndadh gu glutamate. cleachdadh, tha iomadachadh ann an ceallan a tha a 'fàs gu luath air a mhilleadh. Tha tumors a tha an urra ri glutamine an urra ri bhith ag atharrachadh glutamine exogenous gu metabolites glutamate agus glutamate gus an dà chuid lùth a thoirt seachad agus gus blocaichean togail a ghineadh airson macromolecules a dhèanamh, a tha a dhìth airson fàs cealla agus mairsinn."

Targaid: Glutaminase