ABV-744

Ainm Ceimigeach:

N-ethyl-4-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H -pyrrolo[2,3-c]pyridine-2-carboxamide

Còd SMILES:

O = C(C(N1)=CC(C(C(C2=CC(C)(C)(O)C)=CC=C2OC3=C(C)C=C(F)C=C3C)=CN4C)=C1C4) =O) NCC

Còd InChi:

InChI=1S/C28H30FN3O4/c1-7-30-26(33)22-13-20-21(14-32(6)27(34)24(20)31-22)19-12-17( 28(4,5)35)8-9-23(19)36-25-15(2)10-18(29)11-16(25)3/h8-14,31,35H,7H2,1- 6H3,(H,30,33)

iuchair InChi:

OEDSFMUSNZDJFD-UHFFFAOYSA-N

Facal-luirg:

ABBV-744, ABBV 744, ABBV744, 2138861-99-9

Solubility:Soluble ann an DMSO

Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan).

Tuairisgeul:

Tha ABBV-744 na neach-dìon bromodomain BET roghnach BDII a thathas a’ sgrùdadh gus làimhseachadh AML agus aillse prostate meataigeach a tha an aghaidh sèididh.

Targaid: BET bromodomain