H3B-6527

Ainm Ceimigeach:

N-(2-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)-5-(4-ethylpiperazin-1-yl) phenyl) acrylamide

Còd SMILES:

C=CC(NC1=CC(N2CCN(CC)CC)CC2)=CC=C1NC3=NC=NC(N(C(NC4=C(Cl)C(OC)=CC(OC)=C4Cl)=O)C) =C3) = O

Còd InChi:

InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34- 23-16-24(33-17-32-23)37(3 )29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2 ,2-5H3,(H,35,40)(H,36,41)(H,32,33,34)

iuchair InChi:

MBWRLLRCTIYXDW-UHFFFAOYSA-N

Facal-luirg:

H3B-6527, H3B 6527, H3B6527, 1702259-66-2

Solubility:Soluble ann an DMSO

Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan).

Tuairisgeul:

Tha H3B-6527 (H3 Biomedicine) na neach-dìon FGFR4 air leth roghnach le gnìomhachd làidir antitumour ann an loidhnichean cealla meudaichte FGF19 agus luchagan.

Targaid: FGFR4