Batefenterol
Mion-fhiosrachadh toraidh
Bathar Tags
| Meud pacaid | Ri fhaotainn | Prìs (USD) |
| 50mg | Anns a’ bhùth | 200 |
| 250mg | Anns a’ bhùth | 600 |
| 500mg | Anns a’ bhùth | 900 |
| 1g | Anns a’ bhùth | 1400 |
| Barrachd mheudan | Faigh Quotes | Faigh Quotes |
Ainm Ceimigeach:
"(R) -1-(3-((2-chloro-4-((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl) amino) methyl)-5-methoxyphenyl) amino)-3-oxopropyl) piperidin-4-yl [1,1'-biphenyl] -2-ylcarbamate Batefenterol Succinate"
Còd SMILES:
O=C(OC1CCN(CCC(NC2=CC(OC)=C(CNC[C@H)(O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)= O) CC1)NC5=CC=CC=C5C6=CC=CC=C6
Còd InChi:
InChI=1S/C40H42ClN5O7/c1-52-36-22-33(31(41)21-26(36)23-42-24-35(48)29-11-13-34(47)39-30( 29)12-14-37(49)45-39)43-38(50)17-20-46-18-15-27(16-19-46)53-40(51)44-32-10- 6-5-9-28(32)25-7-3-2-4-8-25/h2-14,21-22,27,35,42,47-48H,15-20,23-24H2, 1H3,(H,43,50)(H,44,51)(H,45,49)/t35-/m0/s1
iuchair InChi:
URWYQGVSPQJGGB-DHUJRADRSA-N
Facal-luirg:
Batefenterol, TD-5959, GSK961081, 743461-65-6, GSK-961081, GSK 961081, TD5959, TD 5959, 743461-65-6
Solubility:Soluble ann an DMSO
Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan)
Tuairisgeul:
Tha Batefenterol na antagonist muscarinic agus agonist receptor β2-adrenergic (β2-AR) (Kis = 1.4, 1.3, agus 3.7 nM, airson hM2, hM3, agus hβ2-AR, fa leth ann am measadh ceangail radioligand). Tha Batefenterol a’ taisbeanadh gnìomhachd làidir agonist hβ2-AR (EC50 = 0.29 nM) le roghnachd gnìomh 440- agus 320-fold thairis air hβ1- agus hβ3-ARs, fa leth. inneal agus a’ bacadh freagairt bronchoconstrictor ann an assay bronchoprotection muc ghuine (ED50 = 6.4 µg / mL). Tha foirmlean anns a bheil batefenterol ann an deuchainnean clionaigeach gus làimhseachadh galar sgamhain cnap-starra cronach (COPD).
Targaid: β2-adrenoceptor
