Bardoxolone methyl

Ainm Ceimigeach:

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-methyl 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a, 9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate

Còd SMILES:

O=C([C@]1(CC[C@])2(C)(C@]3(C)CCC4C(C)(C)C(C(C#N))=C[C@]4 (C)C3=C5)=O)CCC(C)(C)C[C@]1(H])(C@@]2([H])C5=O)OC

Còd InChi:

InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15- 23-29(5)16-19(18-33) 25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22 ?,24+,29+,30-,31-,32+/m1/s1

iuchair InChi:

WPTTVJLTNAWYAO-OROHISIGSA-N

Facal-luirg:

Bardoxolone methyl, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, Methyl CDDO, CDDO methyl ester, 218600-53-4

Solubility:Soluble ann an DMSO

Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan)

Tuairisgeul:

Tha an CDDO oleanane triterpenoid synthetigeach (Nì. Bidh an ester C-28 methyl de CDDO (CDDO methyl ester) a’ blocadh synthesis ceallach de synthase nitric oxide inducible (iNOS) agus COX-2 inducible ann am macrophages luchag gnìomhaichte INF-γ le luach IC50 de 0.11 nM. Bidh e a 'toirt a-steach apoptosis, a' toirt air adhart eadar-dhealachadh, agus a 'cur bacadh air an fhreagairt shàmhach ann an diofar cheallan tumhair tro bhith a' bacadh comharran IκBα kinase / NF-κB. Tha gnìomhachd antidiabetic làidir aig CDDO methyl ester, a’ lughdachadh abairt cytokine proinflammatory ann an luchagan diabetic seòrsa 2 le daithead àrd geir agus ann an luchagan Leprdb / db agus a’ piobrachadh kinase pròtain gnìomhaichte AMP agus gnìomhachd LKB1 ann am fèithean agus grùthan.

Targaid: NF-kB