ARS-1620
Mion-fhiosrachadh toraidh
Bathar Tags
| Meud pacaid | Ri fhaotainn | Prìs (USD) |
| 100mg | Anns a’ bhùth | 800 |
| 500mg | Anns a’ bhùth | 1500 |
| 1g | Anns a’ bhùth | 2000 |
| Barrachd mheudan | Faigh Quotes | Faigh Quotes |
Ainm Ceimigeach:
(S)-1-(4-(6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one)
Còd SMILES:
C=CC(=O)N1CCN(CC1)C2=C3C=C(C(=C4C(=O)C=CC=C4F)C(=C3NC=N2)F)Cl
Còd InChi:
InChI=1S/C21H17ClF2N4O2/c1-2-16(30)27-6-8-28(9-7-27)21-12-10-13(22)17( 19(24)20(12)25-11-26-21)18-14(23)4-3-5-15(18)29/h2-5,10-11,29H,1,6-9H2
iuchair InChi:
QIQWMIZVWVSRAS-UHFFAOYSA-N
Facal-luirg:
ARS-1620, KRAS G12C, NSCLC, ARS1620, ARS 1620, KRASG12C, 1698055-85-4
Solubility:Soluble ann an DMSO
Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan)
Tuairisgeul:
Tha ARS-1620 na phrodrug air a dhealbhadh bho ARS-853, a tha na neach-dìon S-IIP G12C cumhachdach agus roghnach. Thathas an dùil gum bi ARS-1620 na ro-innleachd teirpeach airson aillsean mutant p.G12C KRAS.
Targaid: KRAS (K-Ras G12C)
