THZ2

Ainm Ceimigeach:

N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-3-[[(E)-4-(dimethylamino)but-2- enoyl] amino] benzamide

Còd SMILES:

O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=CC(NC(C=C/CN) (C)C)=O)=C5

Còd InChi:

InChI=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6- 11-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-13-4-3-12-24(25)27/h3- 14,16-19,33H,15H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b14-7+

iuchair InChi:

FONRCZUZCHXWBD-VGOFMYFVSA-N

Facal-luirg:

THZ-2, THZ 2, THZ2, 1604810-84-5

Solubility:Soluble ann an DMSO

Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan).

Tuairisgeul:

THZ2, analog de THZ1, le comas air aillse broilleach trì-àicheil (TNBC) a làimhseachadh, tha e na neach-dìon CDK7 cumhachdach agus roghnach a tha a’ faighinn thairis air neo-sheasmhachd THZ1 in vivo. IC50: CDK7 = 13.9 nM; ceallan TNBC = 10 nM

Targaid: CDK