STING agonist-4

Enw Cemegol:

1,1'- (bwtan-1,4-diyl)bis(2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1H-benso[d]imidazole-5-carboxamide)

Cod gwenu:

O=C(C1=CC=C2N(CCCCN3C(NC(C4=CC(C)=NN4CC)=O)=NC5=CC(C(N)=O)=CC=C35)C(NC(C6=CC)) (C)=NN6CC)=O)=NC2=C1)N

Cod InChi:

InChI=1S/C34H38N12O4/c1-5-45-27(15-19(3)41-45)31(49)39-33-37-23- 17-21(29(35)47)9-11-25(23)43(33)13-7-8-14-44-26-12-10-22(30(36)4 8)18-24(26)38-34(44)40-32(50)28-16-20(4)42-46(28)6-2/h9-12,15-18 H,5-8,13-14H2,1-4H3,(H2,35,47)(H2,36,48)(H,37,39,49)(H,38,40,50)

Allwedd InChi:

ICZSAXDKFXTSGL-UHFFFAOYSA-N

Allweddair:

Hydoddedd: 

Storio: 

Disgrifiad:

Mae STING agonist-4 yn symbylydd gweithydd derbynnydd Interferon Genes (STING) gyda chysonyn ataliol ymddangosiadol (IC50) o 20 nM. Mae STING agonist-4 yn gyfansoddyn seiliedig ar amidobenzimidazole (ABZI) sy'n gysylltiedig â dau gymesuredd i greu ABZIs (diABZIs) cysylltiedig gyda rhwymiad gwell i STING a swyddogaeth gellog.

Targed: STING