STING agonist-3

STING agonist-3
  • Enw:STING agonist-3
  • Rhif catalog:DPP101231
  • Rhif CAS:2138299-29-1
  • Pwysau moleciwlaidd:750.8
  • Fformiwla Cemegol:C37 H42 N12 O6
  • Ar gyfer ymchwil wyddonol yn unig, nid ar gyfer cleifion.

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    Enw Cemegol:

    (E)-1-(4-(5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido))-1H-benso[d]imidazol-1-yl)but-2- cy-1- yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-hydroxypropoxy)-1H-benso[d]imidazole-5-carboxamide

    Cod gwenu:

    O=C(N)C1=CC=C(N(C(NC(C2=CC(C))=NN2CC)=O)=N3)C/C=C/CN4C5=C(N=C4NC(C6=CC) (C)=NN6CC)=O)C=C(C(N)=O)C=C5OCCCO)C3=C1

    Cod InChi:

    InChI=1S/C37H42N12O6/c1-5-48-28(16-21(3)44-48)34(53)42-36-40-25-18-23(3 2(38)51)10-11-27(25)46(36)12-7-8-13-47-31-26(19-24(33(39)52)20-30(31)55- 15-9-14-50)41-37(47)43-35(54)29-17-22(4)45-49(29)6-2/h7-8,10-11,16-20, 50 H,5-6,9,12-15H2,1-4H3,(H2,38,51)(H2,39,52)(H,40,42,53)(H,41,43,54)/b8 -7+

    Allwedd InChi:

    VHCDRDBBENBVEK-BQYQJAHWSA-N

    Allweddair:

    Hydoddedd: 

    Storio: 

    Disgrifiad:

    Mae agonist STING-3, a dynnwyd o batent WO2017175147A1 (enghraifft 10), yn weithydd STING moleciwlaidd bach dethol a di-niwcleotid gyda pEC50 a pIC50 o 7.5 a 9.5, yn y drefn honno. Mae gan agonist STING-3 effaith gwrth-tiwmor wydn a photensial aruthrol i wella triniaeth canser

    Targed: STING


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