I-Adavivint

Igama Lekhemikhali:

N-(5-{3-[7-(3-fluorophenyl))-1H-imidazo[4,5-c]pyridin-2-yl]-1H-indazol-5-yl}pyridin-3-yl)-3 - methylbutanamide

Ikhodi ye-SMILES:

CC(C)CC(NC1=CC(C2=CC3=C(NN=C3C(N4)=NC5=C4C(C6=CC=CC(F)=C6)=CN=C5)C=C2)=CN= C1)=O

Ikhodi ye-InChi:

I-InChI=1S/C29H24FN7O/c1-16(2)8-26(38)33-21-10-19(12-31-13-21)17-6-7-24-22(11-17)28( 37-36-24)29-34 -25-15-32-14-23(27(25)35-29)18-4-3-5-20(30)9-18/h3-7,9-16H,8H2,1-2H3,( H,33,38)(H,34,35)(H,36,37)

I-InChi Key:

AQDWDWAYVBQMAM-UHFFFAOYSA-N

Igama elingukhiye:

Adavivint, SM04690, SM-04690, SM 04690, 1467093-03-3

Ukunyibilika:I-Soluble ku-DMSO

Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).

Incazelo:

Inoveli encane ye-molecule ye-Wnt pathway inhibitor ene-EC50 ye-3 nM in vitro; yenza ukuhlukaniswa kwe-hMSC ibe ama-chondrocyte avuthiwe, asebenzayo futhi yehlise amazinga omaka we-cartilage catabolic; ithuthukisa kakhulu izikolo ze-histology ye-Osteoarthritis Research Society International (OARSI) kanye nama-biomarker kumodeli ye-OA yegundane.

Ithagethi: WNT