I-AZD-5069
Imininingwane Yomkhiqizo
Omaka bomkhiqizo
| Usayizi Wephakethe | Ukutholakala | Intengo (USD) |
| 100mg | Kukhona kusitoki | 500 |
| 500mg | Kukhona kusitoki | 800 |
| 1g | Kukhona kusitoki | 1200 |
| Osayizi abengeziwe | Thola Izingcaphuno | Thola Izingcaphuno |
Igama Lekhemikhali:
N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pyrimidin-4-yl)azetidine-1-sulfonamide
Ikhodi ye-SMILES:
O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O
Ikhodi ye-InChi:
I-InChI=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22- 16)30-10-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2, 1H3,(H,21,22,23)/t11-,14+/m1/s1
I-InChi Key:
QZECRCLSIGFCIO-RISCZKNCSA-N
Igama elingukhiye:
AZD-5069, AZD5069, AZD 5069, 878385-84-3
Ukunyibilika:I-Soluble ku-DMSO
Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga).
Incazelo:
I-AZD-5069 iyimbangi ye-CXCR2 enamandla futhi ekhethayo enamandla okuvimbela ukufuduka kwe-neutrophil emigwaqweni yomoya ezigulini ezine-COPD. I-AZD-5069 iboniswe ukuthi ivimbela ukubophezela kwe-CXCL8 ene-radiolebele ku-CXCR2 yomuntu enevelu ye-pIC50 engu-9.1. Ngaphezu kwalokho, i-AZD5069 ivimbele i-neutrophil chemotaxis, ene-pA2 ecishe ibe ngu-9.6, kanye nenkulumo ye-molecule yokunamathela, ene-pA2 ye-6.9, ekuphenduleni i-CXCL1. I-AZD5069 yayingumphikisi obuyisele emuva kancane kancane we-CXCR2 enemiphumela yesikhathi nezinga lokushisa okubonakala kusayensi yezemithi kanye ne-kinetics ebophayo. I-AZD-5069 futhi ingaba usizo esigulini ezimeni ezivuvukalayo.
Ithagethi: CXCR2