I-AZD7507

Igama Lekhemikhali:

4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide

Ikhodi ye-SMILES:

O=C(C1=NN=C2C=C(OC)C(N3CCN(CCO)CC3)=CC2=C1NC4=CC=C(C)C=C4F)N

Ikhodi ye-InChi:

I-InChI=1S/C23H27FN6O3/c1-14-3-4-17(16(24)11-14)26-21-15-12-19(30-7-5-29(6-8-30)9- 10-31)20(33-2)13-18(15)27-28-22(21)23(25)32/h3-4,11-13,31H,5-10H2,1-2H3,(H2 ,25,32)(H,26,27)

I-InChi Key:

CPDGCAFPSYOTGO-UHFFFAOYSA-N

Igama elingukhiye:

I-AZD7507; I-AZD-7507; I-AZD 7507

Ukunyibilika:I-DMSO

Isitoreji: 

Incazelo:

I-AZD7507 iyi-CSF-1R inhibitor enamandla futhi ekhethayo (32 nM cell function), i-AZD7507 ithathwa njengenhlanganisela ethembisayo njengoba igcine amandla adingekayo kanye nezakhiwo ze-pharmacokinetic zomlomo ze-AZ683. Ngaphezu kwalokho, ocwaningweni lwe-telemetry ezinjeni ezinikezwe umthamo owodwa womlomo, kwakungekho ubuthi benhliziyo, akukho ukuphakama kwe-troponin okuhlobene nokwelashwa, futhi akukho ukuguqulwa ku-ECG.

Ithagethi: CSF-1R