I-Vactosertib
Imininingwane Yomkhiqizo
Omaka bomkhiqizo
| Usayizi Wephakethe | Ukutholakala | Intengo (USD) |
| 500mg | Kukhona kusitoki | 800 |
| 1g | Kukhona kusitoki | 1300 |
| 5g | Kukhona kusitoki | 3800 |
| Osayizi abengeziwe | Thola Izingcaphuno | Thola Izingcaphuno |
Igama Lekhemikhali:
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl )-2-fluoroaniline
Ikhodi ye-SMILES:
FC1=CC=CC=C1NCC2=NC(C3=CN4C(C=C3)=NC=N4)=C(C5=NC(C)=CC=C5)N2
Ikhodi ye-InChi:
I-InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12- 15)28-19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29 )
I-InChi Key:
FJCDSQATIJKQKA-UHFFFAOYSA-N
Igama elingukhiye:
Vactosertib, EW-7197, EW7197, EW 7197, 1352608-82-2
Ukunyibilika:I-Soluble ku-DMSO
Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)
Incazelo:
I-Vactosertib, eyaziwa nangokuthi i-EW-7197 iyi-ALK5 inhibitor enamandla. I-EW-7197 ibonise umsebenzi onamandla ku-vivo anti-metastatic, okubonisa amandla ayo okusetshenziswa njengendlela yokwelapha yokulwa nomdlavuza. I-EW-7197 ivimbela ukusayina kwe-TGF-β/Smad. I-EW-7197 ichitha ukufuduka nokuhlasela kwe-tumor cell ye-TGF-β1. I-EW-7197 ivimbela i-metastasis yomdlavuza webele emaphashini.EW-7197 yelula isikhathi sempilo yamagundane e-BALB/c 4T1 ngokuvinjelwa kwe-EMT. I-EW-7197 ivimbela i-metastasis futhi ithuthukisa umsebenzi we-cytotoxic T lymphocytes (CTLs) kumagundane axhunyelelwe amathambo angu-4T1.
Ithagethi: ALK
