BI-847325
Imininingwane Yomkhiqizo
Omaka bomkhiqizo
| Usayizi Wephakethe | Ukutholakala | Intengo (USD) |
| 100mg | Kukhona kusitoki | 400 |
| 500mg | Kukhona kusitoki | 950 |
| 1g | Kukhona kusitoki | 1400 |
| Osayizi abengeziwe | Thola Izingcaphuno | Thola Izingcaphuno |
Igama Lekhemikhali:
(Z)-3-(3-(((4-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindolin-6-yl)-N-ethylpropiolamide
Ikhodi ye-SMILES:
O=C(NCC)C#CC1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(CN(C)C)C=C3)/C4=CC= CC=C4
Ikhodi ye-InChi:
I-InChI=1S/C29H28N4O2/c1-4-30-26(34)17-13-20-12-16-24-25(18-20)32-29(35)27(24)28(22-8- 6-5-7-9-22)31-23-14-10-21(11-15-23)19-33(2)3/h5-12,14-16,18,31H,4,19H2, 1-3H3,(H,30,34)(H,32,35)/b28-27-
I-InChi Key:
FLBNLJLONKAPLR-DQSJHHFOSA-N
Igama elingukhiye:
BI-847325, BI847325, BI 847325, 1207293-36-4
Ukunyibilika:I-Soluble ku-DMSO
Isitoreji:0 - 4°C isikhathi esifushane (izinsuku ukuya emavikini), noma -20°C isikhathi eside (izinyanga)
Incazelo:
I-BI-847325 iyi-dual inhibitor ye-MEK/Aurora kinase enamanani e-IC50 angu-3, 25, 15, 25, no-4 nM we-X. laevis Aurora B, i-Aurora A yomuntu kanye ne-Aurora C, kanye ne-MEK1 yomuntu kanye ne-MEK2 ngokulandelanayo. Ingavimbela ukukhula nokuphila kwayo yomibili imigqa yeseli ye-melanoma engalapheki futhi engazweli emuthini, yehlise ukusho kwe-MEK ne-Mcl-1 kuyilapho ikhulisa ukubonakaliswa kwe-pro-apoptotic protein Bim. Ku-70 mg/kg, i-BI-847325 idala i-apoptosis ku-melanoma ye-xenografted engazweli ekwelapheni futhi emelana nomuthi ku-vivo.
Ithagethi: MEK/Aurora
