I-AMG-510

I-AMG-510
  • Igama:I-AMG-510
  • Inombolo yekhathalogi:I-CPD2809
  • Inombolo ye-CAS:2296729-00-3, (2252403-56-6 racemate)
  • Isisindo se-Molecular:560.23
  • I-Chemical Formula:I-C30H30F2N6O3
  • Olocwaningo lwesayensi kuphela, hhayi lweziguli.

    Imininingwane Yomkhiqizo

    Omaka bomkhiqizo

    Usayizi Wephakethe Ukutholakala Intengo (USD)
    1g kukhona kusitoki 1300
    5g kukhona kusitoki 6000
    10g kukhona kusitoki 10500

    Igama Lekhemikhali:

    4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl )pyrido[2,3-d]pyrimidin-2(1H)-one

    Ikhodi ye-SMILES:

    O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C (C5=C(O)C=CC=C5F)=N4)=O)CC1

    Ikhodi ye-InChi:

    I-InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8- 7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6- 11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1

    I-InChi Key:

    NXQKSXLFSAEQCZ-SFHVURJKSA-N

    Igama elingukhiye:

    I-AMG-510; AMG 510; I-AMG510

    Ukunyibilika: 

    Isitoreji: 

    Incazelo:

    I-AMG-510 iyisivimbeli esinamandla se-KRAS G12C. I-AMG-510 iqondise ngokukhetha inguquko ye-KRAS p.G12C, ezingeni le-DNA, i-RNA noma iphrotheni, futhi ivimbela, ngendlela engakacaciswanga, ukubonakaliswa kanye/noma noma ukusayina kweseli lesimila nge-KRAS p.G12C mutant. Lokhu kungase kuvimbele ukukhula kumaseli e-KRAS p.G12C-eveza isimila

    Ithagethi: KRAS


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