RGX-104 HCl

Orukọ Kemikali:

(R) -2- [3-[3-[[2-Chloro-3- (trifluoromethyl) benzyl] (2,2-diphenylethyl) amino]-3-methylpropoxy] phenyl] acetic acid hydrochloride.

KỌỌDỌ SMILES:

O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4 =CC=CC=C4)C)=C1.[H]Cl

Koodu InChi:

InChI=1S/C34H33ClF3NO3.ClH/c1-24(18-19-42-29-16-8-10-25(20-29)21-32(40)41)39(22-28-15-9- 17-31 (33 (28)35)34 (36,37)38)23-30 (26-11-4-2-5-12-26)27-13-6-3-7-14-27; /h2-17,20,24,30H,18-19,21-23H2,1H3,(H,40,41);1H/t24-;/m1./s1

Bọtini InChi:

LCMIYQOJZLRHTO-GJFSDDNBSA-N

Koko-ọrọ:

RGX-104 HCl, RGX-104, RGX104, RGX 104, 610318-03-1

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).

Apejuwe:

RGX-104 jẹ agonist beta olugba ẹdọ X ti o ni agbara imunomodulating ati awọn iṣẹ antineoplastic. Lori iṣakoso ẹnu, RGX-104 yan awọn ibi-afẹde ati sopọ mọ LXRbeta, nitorinaa mu ifihan agbara-alaja LXRbeta ṣiṣẹ, ti o yori si kikọsilẹ ti awọn jiini ti o dinku tumo ati idinku ti awọn jiini olupolowo tumo kan. Eyi paapaa mu ikosile ti apolipoprotein E (ApoE) ṣiṣẹ, amuaradagba ti o dinku tumo, ninu awọn sẹẹli tumo ati awọn sẹẹli ajẹsara kan. Eyi n mu eto ajẹsara ti ajẹsara ṣiṣẹ, ti o mu ki idinku awọn sẹẹli suppressor myeloid-derived immunosuppressive (MDSCs), awọn sẹẹli tumo ati awọn sẹẹli endothelial ninu microenvironment tumo. Eyi yiyipada imukuro ajẹsara, mu awọn idahun ajẹsara egboogi-tumor ṣe ati ṣe idiwọ itankale awọn sẹẹli tumo.

afojusun: LXRbeta