NTN21277

Orukọ Kemikali:

(2S, 4R) -1- ((S) -2- (3- (2-- ((5-)- ((4-- (3-chloro-4-fluorophenyl)) amino)-7-methoxyquinazolin-6-yl) oxy) pentyl) oxy) ethoxy) propanamido) -3,3-dimethylbutanoyl) -4-hydroxy-N- (4- (4-methylthiazol-5-yl) benzyl) pyrrolidine-2-carboxamide

KỌỌDỌ SMILES:

O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC )=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

Koodu InChi:

InChi=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-3 3(57)26-56(38)46(60)43(47(2,3)4)55-41(58)15-18-63-20-19-62-16-7-6-8- 17-64-40-23-34-37 (24-39 (40)61-5)51-27-52-44 (34)54-32-13-14-36(49)35(48)21-32/h9-14,21,23-24 ,27-28,33,3 8,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55,58)(H,51,52,54)/t33- ,38+,43- / m1 / s1

Bọtini InChi:

NICKHWYZMNLEPJ-TZSMONEZSA-N

Koko-ọrọ:

Gefitinib-orisun PROTAC 3; NTN21277; NTN-21277; NTN 21277

Solubility: 

Ibi ipamọ: 

Apejuwe:

NTN21277, ti a tun mọ ni Gefitinib-orisun PROTAC 3 jẹ PROTAC igbanisiṣẹ VHL ti o fa ibajẹ ti EGFR ati awọn ẹda EGFR pẹlu DC50 ti 11.7 nM ati 22.3 nM fun sẹẹli HCC827 (Exon 19 del) ati sẹẹli H3258R (L).

afojusun: EGFR