JBJ-04-125-02 R-isomer
Alaye ọja
ọja Tags
| Iwọn Pack | Wiwa | Iye owo (USD) |
Orukọ Kemikali:
(R) -2- (5-fluoro-2-hydroxyphenyl) -2- (1-oxo-6- (4- (piperazin-1-yl) phenyl) isoindolin-2-yl) - N- (thiazol-2). -yl) acetamide
KỌỌDỌ SMILES:
O=C([C@H](N(C1=O)CC2=C1C=C(C=C2)C3=CC=C(C=C3)N4CCNCC4)C5=CC(F)=CC=C5O)NC6 =NC=CS6
Koodu InChi:
InChi=1S/C29H26FN5O3S/c30-21-5-8-25(36)24(16-21)26(27(37)33-29-32-11-14-39-29)35-17-20- 2-1-19 (15-23 (20)28 (35) 38) 18-3-6-22 (7-4-18) 34-12-9-31-10-13-34 / h1-8, 11,14-16,26,31,36H,9-10,12-13,17H2,(H,32,33,37)/t26-/m1/s1
Bọtini InChi:
VHQVOTINPRYDAO-AREMUKBSSA-N
Koko-ọrọ:
Solubility:
Ibi ipamọ:
Apejuwe:
JBJ-04-125-02 jẹ oludaniloju EGFR allosteric ti o yan-iyipada pẹlu iṣẹ-ṣiṣe anticancer ti o pọju. Gẹgẹbi oluranlowo ẹyọkan, o le ṣe idiwọ ilọsiwaju sẹẹli ati EGFRL858R/T790M/C797S ifihan agbara ni vitro ati ni vivo. Apapọ osimertinib ati JBJ-04-125-02 awọn abajade ni ilosoke ninu apoptosis, idinamọ ti o munadoko diẹ sii ti idagbasoke cellular, ati ipa ti o pọ si ni vitro ati ni vivo ni akawe pẹlu boya aṣoju kan ṣoṣo.
afojusun: EGFR
