EAI-045

Orukọ Kemikali:

2- (5-fluoro-2-hydroxyphenyl) -2- (3-oxo-1H-isoindol-2-yl) - N- (1,3-thiazol-2-yl) acetamide

KỌỌDỌ SMILES:

O=C(NC1=NC=CS1)C(C2=CC(F)=CC=C2O)N3CC4=C(C=CC=C4)C3=O

Koodu InChi:

InChi=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8-27-19)23-10-11- 3-1-2-4-13 (11)18 (23)26/h1-9,16,24H,10H2,(H,21,22,25)

Bọtini InChi:

YTUFHOKUFOQRDF-UHFFFAOYSA-N

Koko-ọrọ:

EAI-045, EAI045, EAI 045, 1942114-09-1

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu)

Apejuwe:

EAI045 jẹ oludawọle EGFR ti o lagbara ati yiyan. Awọn ibi-afẹde EAI045 ti a yan awọn ẹda EGFR ti o ni sooro oogun ṣugbọn ṣe itọju olugba iru-igi. EAI045 ṣe idiwọ L858R/T790M-mutant EGFR pẹlu agbara kekere-nanomolar ninu awọn igbelewọn biokemika.

afojusun: EGFR