IT-901

Orukọ Kemikali:

5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H) -pyrimidinedione

KỌỌDỌ SMILES:

O=C(/C(C(N1)=O)=CC2=C3C=CC=CC3=C(OC)C=C2OC)NC1=S

Koodu InChi:

InChi=1S/C17H14N2O4S/c1-22-13-8-14(23-2)11(9-5-3-4-6-10(9)13)7-12-15(20)18-17( 24)19-16 (12)21/h3-8H,1-2H3,(H2,18,19,20,21,24)

Bọtini InChi:

JHOPCCOYRKEHQU-UHFFFAOYSA-N

Koko-ọrọ:

IT-901, IT901, IT 901, 1584121-99-2

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).

Apejuwe:

"IT-901 jẹ inhibitor c-Rel Ti o ṣe agbero Awọn ohun-ini Anticancer ni Awọn aiṣedeede Hematologic nipasẹ didi Awọn idahun Wahala Oxidative NF-κB-Iṣakoso. IT-901 ni agbara ṣe idiwọ NF-κB subunit c-Rel. IT-901 ti tẹmọlẹ alọmọ-dipo- Arun ogun lakoko ti o tọju iṣẹ alọmọ-laisi-lymphoma lakoko igbelewọn itọsi siwaju sii ti IT-901 fun itọju ti lymphoma B-cell ti eniyan ṣafihan awọn ohun-ini antitumor ni vitro ati ni vivo laisi ihamọ si NF-κB-ti o gbẹkẹle lymphoma. 901 ko ṣe afihan awọn ipele ti o pọ si ti awọn ẹya atẹgun ifaseyin ni awọn leukocytes deede, ti n ṣapejuwe awọn ohun-ini yiyan alakan rẹ IT-901 jẹ aṣoju itọju aramada lati tọju awọn èèmọ lymphoid eniyan ati alọrun-dipo-ogun.

Àfojúsùn: NF-kB