TH-302; Evofosfamide
Alaye ọja
ọja Tags
| Iwọn Pack | Wiwa | Iye owo (USD) |
| 100mg | O wa | 360 |
| 1g | O wa | 1000 |
| Awọn iwọn diẹ sii | Gba Awọn asọye | Gba Awọn asọye |
Orukọ Kemikali:
N, N'-Bis (2-bromoethyl) phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazole-5-yl) methyl ester
KỌỌDỌ SMILES:
O=P(NCCBr)(NCCBr)OCC1=CN=C([N+]([O-])=O)N1C
Koodu InChi:
InChi=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/ h6H,2-5,7H2,1H3,(H2,13,14,19)
Bọtini InChi:
UGJWRPJDTDGERK-UHFFFAOYSA-N
Koko-ọrọ:
TH-302, TH302, TH 302, Evofosfamide, 918633-87-1
Solubility:Tiotuka ni DMSO
Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu)
Apejuwe:
Evofosfamide, ti a tun mọ ni TH-302, jẹ prodrug ti a mu ṣiṣẹ hypoxia ti o ni 2-nitroimidazole phosphoramidate conjugate pẹlu iṣẹ antineoplastic ti o pọju. 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 sise bi a hypoxic okunfa, dasile DNA-alkylating dibromo isophosphoramide mustard moiety laarin awọn agbegbe hypoxic ti awọn èèmọ. Awọn tisọ Normoxic le ni ipamọ nitori iṣẹ-ṣiṣe pato hypoxia ti aṣoju yii, ti o le dinku majele ti eto eto. Ṣayẹwo fun awọn idanwo ile-iwosan ti nṣiṣe lọwọ tabi awọn idanwo ile-iwosan pipade ni lilo aṣoju yii. (NCI).
Àkọlé: DNA Alkylating Agent
