BLU-9931
Alaye ọja
ọja Tags
| Iwọn Pack | Wiwa | Iye owo (USD) |
| 100mg | O wa | 220 |
| 300mg | O wa | 500 |
| 1g | O wa | 1350 |
| Awọn iwọn diẹ sii | Gba Awọn asọye | Gba Awọn asọye |
Orukọ Kemikali:
N- (2- ((6-- (2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino) -3-methylphenyl) acrylamide
KỌỌDỌ SMILES:
C=CC(NC1=CC=CC(C)=C1NC2=NC=C3C=C(C4=C(Cl)C(OC)=CC(OC)=C4Cl)C=CC3=N2)=O
Koodu InChi:
InChi=1S/C26H22Cl2N4O3/c1-5-21(33)30-18-8-6-7-14(2)25(18)32-26-29-13-16-11-15(9-10- 17 (16) 31-26) 22-23 (27) 19 (34-3) 12-20 (35-4)24 (22)28/h5-13H,1H2,2-4H3, (H,30,33 ) (H,29,31,32)
Bọtini InChi:
TXEBNKKOLVBTFK-UHFFFAOYSA-N
Koko-ọrọ:
BLU-9931, BLU9931, BLU 9931, 1538604-68-0
Solubility:Tiotuka ni DMSO
Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu).
Apejuwe:
Ninu awọn sẹẹli MDA-MB-453, BLU9931 ni agbara ni idinamọ phosphorylation ti ipa ọna ifihan FGFR4. BLU9931 ṣe idiwọ itankale awọn laini sẹẹli HCC ti o ṣafihan eka ifamisi FGFR4 aipe, gẹgẹbi Hep 3B, HUH-7, ati awọn laini sẹẹli JHH-7, pẹlu EC50 ti<1 μM. BLU9931 tun ṣe idiwọ ilọsiwaju ni awọn laini sẹẹli ti a mu PDX pẹlu ipa ọna ifihan FGFR4 aipe[1]. BLU9931 n fa idinku tumo ninu awọn awoṣe carcinoma hepatocellular ti o ṣe afihan ligand ti n ṣiṣẹ / eka olugba ti o wa ninu FGF19/FGFR4/KLB ati pe o ṣe afikun si atokọ dagba ti awọn aṣoju anti-FGFR4[2].
Ifojusi: FGFR4
