AZD8186

Orukọ Kemikali:

(R) -8- (1- ((3,5-difluorophenyl) amino) ethyl) -N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

KỌỌDỌ SMILES:

O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4) =O)=C1

Koodu InChi:

InChi=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3 )9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14 -/m1/s1

Bọtini InChi:

LMJFJIDLEAWOQJ-CQSZACIVSA-N

Koko-ọrọ:

AZD8186, AZD-8186, AZD 8186, 1627494-13-6

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu)

Apejuwe:

AZD8186 jẹ ati inhibitor ti isoform beta ti phosphoinotide-3 kinase (PI3K), pẹlu iṣẹ ṣiṣe antineoplastic ti o pọju. Lẹhin iṣakoso, oludena PI3Kbeta AZD8186 yiyan ṣe idiwọ iṣẹ ṣiṣe ti PI3Kbeta ni ipa ọna ifihan PI3K/Akt/mTOR, eyiti o le ja si idinku ti ilọsiwaju sẹẹli tumo. O tun fa iku sẹẹli ni PI3K ti n ṣalaye awọn sẹẹli alakan. Nipa ìfọkànsí pataki kilasi I PI3K beta, aṣoju yii le ni imunadoko diẹ sii ati ki o kere si majele ju awọn inhibitors PI3K pan. Ifitonileti agbedemeji PI3K jẹ igbagbogbo dysregulated ninu awọn sẹẹli alakan ati ṣe alabapin si idagbasoke sẹẹli tumo, iwalaaye, ati idena tumo si ọpọlọpọ awọn aṣoju antineoplastic. AZD8186 wa lọwọlọwọ labẹ awọn idanwo ile-iwosan Ipele I.

Àfojúsùn: PI3K