Quizartinib; AC-010220; AC-220
Alaye ọja
ọja Tags
| Iwọn Pack | Wiwa | Iye owo (USD) |
| 5g | O wa | 1000 |
| 10g | O wa | 1500 |
| Awọn iwọn diẹ sii | Gba Awọn asọye | Gba Awọn asọye |
Orukọ Kemikali:
N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7- (2-morpholin-4-ylethoxy) imidazo[2,1-b][1,3] benzothiazol-2-yl ]phenyl}urea
KỌỌDỌ SMILES:
O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C(C)(C)C)=C6
Koodu InChi:
InChi=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22- 18-35-23-9-8-21 (16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1 -3H3, (H2,30,32,33,36)
Bọtini InChi:
CVWXJKQAOSCOAB-UHFFFAOYSA-N
Koko-ọrọ:
Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1
Solubility:Tiotuka ni DMSO
Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu)
Apejuwe:
Quizartinib jẹ inhibitor ti FMS ti o ni ibatan tyrosine kinase 3 (FLT3; Kd = 1.6 nM) ati ki o ṣe afihan yiyan giga fun FLT3 nigba idanwo lodi si nronu ti 227 afikun kinases. O ṣe idiwọ ilọsiwaju ti laini sẹẹli lukimia eniyan MV4-11, eyiti o ni iyipada homozygous FLT3-ITD, pẹlu iye IC50 ti 0.56 nM.1 Ni 1 mg / kg / ọjọ, quizartinib ti han lati fa iwalaaye ni asin kan. awoṣe ti FLT3-ITD aisan lukimia myeloid nla ati lati pa awọn èèmọ kuro ni igbẹkẹle FLT3 Asin xenograft awoṣe ni 10 mg / kg.
afojusun: FLT3
