Vactosertib

Orukọ Kemikali:

N- ((4- ([1,2,4]triazolo [1,5-a] pyridin-6-yl) -5- (6-methylpyridin-2-yl) -1H-imidazol-2-yl)methyl -2-fluoroaniline

KỌỌDỌ SMILES:

FC1=CC=CC=CC=C1NCC2=NC(C3=CN4C(C=C3)=NC=N4)=C(C5=NC(C)=CC=C5)N2

Koodu InChi:

InChi=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12- 15)28-19 (29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29 )

Bọtini InChi:

FJCDSQATIJKQKA-UHFFFAOYSA-N

Koko-ọrọ:

Vactosertib, EW-7197, EW7197, EW 7197, 1352608-82-2

Solubility:Tiotuka ni DMSO

Ibi ipamọ:0 - 4°C fun igba kukuru (ọjọ si awọn ọsẹ), tabi -20°C fun igba pipẹ (osu)

Apejuwe:

Vactosertib, ti a tun mọ ni EW-7197 jẹ oludena ALK5 ti o lagbara. EW-7197 ṣe afihan agbara ni iṣẹ anti-metastatic vivo, nfihan agbara rẹ fun lilo bi itọju ailera akàn. EW-7197 ṣe idiwọ ifihan TGF-β/Smad. EW-7197 abrogates TGF-β1-induced tumo cell ijira ati ayabo. EW-7197 ṣe idiwọ metastasis akàn igbaya si ẹdọfóró.EW-7197 ṣe gigun gigun aye ti eku BALB/c 4T1 nipasẹ idinamọ ti EMT. EW-7197 ṣe idiwọ metastasis ati imudara iṣẹ ṣiṣe ti awọn lymphocytes T cytotoxic (CTLs) ni 4T1 orthotopic tirun eku.

Àfojúsùn: ALK