I-RGX-104 HCl
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 500 |
| 500mg | Ikhona evenkileni | 800 |
| 1g | Ikhona evenkileni | 1200 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
(R) -2- [3-[3- [[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-3-methylpropoxy]phenyl]acetic acid hydrochloride
Ikhowudi yoncumo:
O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4 =CC=CC=C4)C)=C1.[H]Cl
Ikhowudi ye-InChi:
InChI=1S/C34H33ClF3NO3.ClH/c1-24(18-19-42-29-16-8-10-25(20-29)21-32(40)41)39(22-28-15-9- 17-31(33(28)35)34(36,37)38)23-30(26-11-4-2-5-12-26)27-13-6-3-7-14-27; /h2-17,20,24,30H,18-19,21-23H2,1H3,(H,40,41);1H/t24-;/m1./s1
Isitshixo se-InChi:
LCMIYQOJZLRHTO-GJFSDDNBSA-N
Igama elingundoqo:
I-RGX-104 HCl, RGX-104, RGX104, RGX 104, 610318-03-1
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
I-RGX-104 yi-agonist ye-beta ye-receptor yesibindi ye-X ene-immunomodulating kunye nemisebenzi ye-antineoplastic. Ekulawuleni komlomo, i-RGX-104 ijolise ngokukhethiweyo kwaye ibophelela kwi-LXRbeta, ngaloo ndlela ivula i-LXRbeta-mediated signaling, ekhokelela ekushicilelweni kweentlobo ezithile ze-tumor suppressor genes kunye nokuthotywa kohlobo oluthile lokukhuthaza ithumba. Oku kuvula ngokukodwa ukubonakaliswa kwe-apolipoprotein E (ApoE), iprotheni ye-tumor suppressor, kwiiseli ze-tumor kunye neeseli ezithile zokuzivikela. Oku kuvula amajoni omzimba, okukhokelela ekuphelisweni kweeseli ze-immunosuppressive myeloid-derived suppressor cells (MDSCs), iiseli zethumba kunye neeseli ze-endothelial kwi-tumor microenvironment. Oku kubuyisela umva ukuphepha komzimba, kwandisa iimpendulo ze-anti-tumor immune kunye nokuthintela ukwanda kweeseli zethumba.
Ithagethi: LXRbeta
