GSK2982772
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 500 |
| 500mg | Ikhona evenkileni | 800 |
| 1g | Ikhona evenkileni | 1200 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
(S) -5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b]-[1,4]oxazepin-3-yl)-4H-1,2, 4-triazole-3-carboxamide
Ikhowudi yoncumo:
O=C(C1=NN=C(CC2=CC=CC=C2)N1)N[C@@H]3C(N(C)C4=CC=CC=C4OC3)=O
Ikhowudi ye-InChi:
InChI=1S/C20H19N5O3/c1-25-15-9-5-6-10-16(15)28-12-14(20(25)27)21-19(26)18-22-17(23- 24-18)11-13-7-3-2-4-8-13/h2-10,14H,11-12H2,1H3,(H,21,26)(H,22,23,24)/t14 -/m0/s1
Isitshixo se-InChi:
LYPAFUINURXJSG-AWEZNQCLSA-N
Igama elingundoqo:
GSK-2982772, GSK 2982772, GSK2982772, 1622848-92-3
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
I-GSK2982772 yi-receptor enamandla kunye ne-receptors ekhethiweyo eSebenzayo kwiProtheyini ye-1 (RIP1) i-Kinase eKhethekileyo yoMviwa weKliniki yoNyango lweZifo ezivuthayo. I-GSK2982772, okwangoku ikwisigaba sesi-2a sezifundo zeklinikhi ze-psoriasis, i-rheumatoid arthritis, kunye ne-ulcerative colitis. I-GSK2982772 ibophelela ngokunamandla kwi-RIP1 eneenkcukacha ezigqibeleleyo ze-kinase kwaye inomsebenzi ogqwesileyo wokuthintela iimpendulo ezininzi zeselula ezixhomekeke kwi-TNF. I-RIP1 iye yavela njengento ebalulekileyo ye-upstream kinase ebonakaliswe ukulawula ukuvuvukala ngokusebenzisa i-scaffolding kunye nemisebenzi ethile ye-kinase.
Ithagethi: RIP1
