Quizartinib; AC-010220; AC-220
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 5g | Ikhona evenkileni | 1000 |
| 10g | Ikhona evenkileni | 1500 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
N-(5-tert-Butylisoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-ylethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl ]phenyl} urea
Ikhowudi yoncumo:
O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C)(C)C)=C6
Ikhowudi ye-InChi:
InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22- 18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4- 9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
Isitshixo se-InChi:
CVWXJKQAOSCOAB-UHFFFAOYSA-N
Igama elingundoqo:
Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)
Inkcazo:
I-Quizartinib iyi-inhibitor ye-FMS ehlobene ne-tyrosine kinase 3 (FLT3; Kd = 1.6 nM) kwaye ibonisa ukukhetha okuphezulu kwe-FLT3 xa ivavanywa kwiphaneli ye-227 kinases eyongezelelweyo. Ivimbela ukwanda kwe-leukemia ye-cell line ye-MV4-11, egcina i-homozygous FLT3-ITD ukuguqulwa, kunye nexabiso le-IC50 le-0.56 nM.1 Kwi-1 mg / kg / ngosuku, i-quizartinib ibonakaliswe ukwandisa ukusinda kwimouse. imodeli ye-FLT3-ITD ye-acute myeloid leukemia kunye nokuphelisa amathumba kwimodeli ye-FLT3 exhomekeke kwimouse ye-xenograft kwi-10 mg / kg.
Ithagethi: FLT3
