Vactosertib
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 500mg | Ikhona evenkileni | 800 |
| 1g | Ikhona evenkileni | 1300 |
| 5g | Ikhona evenkileni | 3800 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl )-2-fluoroaniline
Ikhowudi yoncumo:
FC1=CC=CC=C1NCC2=NC(C3=CN4C(C=C3)=NC=N4)=C(C5=NC(C)=CC=C5)N2
Ikhowudi ye-InChi:
InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12-15)28- 19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29)
Isitshixo se-InChi:
FJCDSQATIJKQKA-UHFFFAOYSA-N
Igama elingundoqo:
Vactosertib, EW-7197, EW7197, EW 7197, 1352608-82-2
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga)
Inkcazo:
I-Vactosertib, eyaziwa ngokuba yi-EW-7197 yi-ALK5 inhibitor enamandla. I-EW-7197 ibonise umsebenzi onamandla kwi-vivo anti-metastatic, ebonisa amandla ayo okusetyenziswa njengonyango oluchasene nomhlaza. I-EW-7197 inqanda ukubonakaliswa kwe-TGF-β/Smad. I-EW-7197 itshitshisa i-TGF-β1-eyenziwe i-tumor cell migration kunye nokuhlasela. I-EW-7197 inqanda imetastasis yomhlaza wamabele ukuya kwimiphunga.EW-7197 yandisa ubomi be-BALB/c 4T1 yeempuku ngokuthintelwa kwe-EMT. I-EW-7197 inqanda i-metastasis kwaye iphakamisa umsebenzi we-cytotoxic T lymphocytes (CTLs) kwi-4T1 i-orthotopic grafted mice.
Ithagethi: ALK
