GDC-0077
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 500 |
| 500mg | Ikhona evenkileni | 800 |
| 1g | Ikhona evenkileni | 1200 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
(S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4 ]oxazepin-9-yl)amino)propanamide
Ikhowudi yoncumo:
C[C@@H](C(N)=O)NC1=CC=C(C2=NC(N3[C@H](C(F)F)COC3=O)=CN2CCO4)C4=C1
Ikhowudi ye-InChi:
InChI=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11) 24)2 5-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26) )/t9-,12-/m0/s1
Isitshixo se-InChi:
SGEUNORSOZVTOL-CABZTGNLSA-N
Igama elingundoqo:
GDC-0077, GDC0077, GDC 0077, 2060571-02-8
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
I-GDC-0077 ifumaneka ngomlomo kwaye ikhethiweyo ye-PI3K inhibitor (IC50 = 0.038 + 0.003 nM) kunye> 300-fold selective over other Class I PI3K isoforms. I-GDC-0077 yenza umsebenzi wayo ngokuzibophelela kwindawo yokubopha i-ATP ye-PI3K, ngaloo ndlela inqanda i-phosphorylation ye-PIP2 kwi-PIP3.
Ithagethi: PI3K
