I-BLU-285
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 1g | Ikhona evenkileni | 900 |
| 5g | Ikhona evenkileni | 3600 |
| 10g | Ikhona evenkileni | 6200 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
(S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4 ]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)than-1-amine
Ikhowudi yoncumo:
CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@]](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC= N3)=C2)=C1
Ikhowudi ye-InChi:
InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35( 8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H, 7-10,28H2,1-2H3/t26-/m0/s1
Isitshixo se-InChi:
DWYRIWUZIJHQKQ-SANMLTNESA-N
Igama elingundoqo:
I-BLU-285, i-BLU 285, i-BLU285, i-Avapritinib
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
I-Avapritinib (BLU-285) ibonise umsebenzi we-biochemical in vitro kwi-KIT exon 17 i-enzyme ye-mutant, i-KIT D816V (IC50 = 0.27 nM). Umsebenzi weselula we-Avapritinib kwi-KIT D816 mutants ilinganiswa nge-autophosphorylation kwi-cell mast cell leukemia cell line HMC1.2, kunye ne-P815 i-mouse mastocytoma cell line kunye ne-IC50 = 4 kunye ne-22 nM, ngokulandelanayo. Kwiiseli ze-Kasumi-1, kwi-(8;21)-positive AML line line kunye ne-KIT exon 17 N822K ukuguqulwa, i-Avapritinib ivimbela ngokunamandla i-KIT N822K i-autophosphorylation eguquguqukayo (IC50=40 nM), umqondiso osezantsi, kunye nokwanda kweselula (IC50= 75 nM)[1].
Ithagethi: KIT
