I-BAZ2-ICR
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 500 |
| 500mg | Ikhona evenkileni | 800 |
| 1g | Ikhona evenkileni | 1200 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
4-(4-(1-methyl-1H-pyrazol-4-yl)-1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-1H-imidazol-5-yl)benzonitrile
Ikhowudi yoncumo:
CN(N=C1)C=C1C2=C(C3=CC=C(C#N)C=C3)N(CCC4=CN(C)N=C4)C=N2
Ikhowudi ye-InChi:
InChI=1S/C20H19N7/c1-25-12-16(10-23-25)7-8-27-14-22-19(18-11-24-26(2)13-18)20(27) 17-5-3-15(9-21)4-6-17/h3-6,10-14H,7-8H2,1-2H3
Isitshixo se-InChi:
RRZVGDGTWNQAPW-UHFFFAOYSA-N
Igama elingundoqo:
BAZ2-ICR, BAZ2ICR, BAZ2 ICR, 1665195-94-7
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
I-BAZ2-ICR yiprobe yeekhemikhali egqwesileyo kwizifundo ezisebenzayo ze-BAZ2 bromodomains in vitro kunye ne-vivo. I-bromodomain equkethe iiprotheni ze-BAZ2A / B zidlala indima ebalulekileyo ekuhlaziyweni kwe-chromatin kunye nokulawulwa kwee-RNA ezingenayo ikhowudi. I-BAZ2-ICR ine-IC50 (BAZ2A) = 130 nM; IC50(BAZ2B) = 180 nM; logD = 1.05; ukunyibilika 25 mM (D2O) kunye F = 70%.
Ithagethi: BAZ2