GLPG0187
Iinkcukacha zeMveliso
Iithegi zeMveliso
| Ubungakanani bePakethi | Ubukho | Ixabiso (USD) |
| 100mg | Ikhona evenkileni | 650 |
| 250mg | Ikhona evenkileni | 960 |
| 500mg | Ikhona evenkileni | 1500 |
| Iisayizi ezininzi | Fumana iiQuotes | Fumana iiQuotes |
Igama leMchiza:
(S)-3-((2,5-dimethyl-6-(4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidin-1-yl)pyrimidin-4- yl) amino) -2-((4-methoxyphenyl)sulfonamido)propanoic acid
Ikhowudi yoncumo:
O=C(O)[C@H](CNC1=NC(C)=NC(N2CCC(C3=NC4=C(CCCN4)C=C3)CC2)=C1C)NS(=O)(C5=CC= C(OC)C=C5)=O
Ikhowudi ye-InChi:
InChI=1S/C29H37N7O5S/c1-18-26(31-17-25(29(37)38)35-42(39,40)23-9-7-22(41-3)8-10-23) 32-19(2)33-28(18)36-15-12-20(13) -16-36)24-11-6-21-5-4-14-30-27(21)34-24/h6-11,20,25,35H,4-5,12-17H2,1-3H3 ,(H,30,34)(H,37,38)(H,31,32,33)/t25-/m0/s1
Isitshixo se-InChi:
CXHCNOMGODVIKB-VWLOTQADSA-N
Igama elingundoqo:
GLPG0187, GLPG-0187, GLPG 0187, 1320346-97-1
Ukunyibilika:Inyibilika kwi-DMSO
Ugcino:0 - 4°C ixesha elifutshane (iintsuku ukuya kwiiveki), okanye -20°C ixesha elide (iinyanga).
Inkcazo:
Kwinqanaba eliqinileyo, i-GLPG0187 ibonisa ukukhetha kwii-receptors ezininzi ze-RGD integrin kunye ne-IC50s ye-1.3, 3.7, 2.0, 1.4, 1.2, 7.7 nM ye-αvβ1, αvβ3, αvβ5, αvβ6, αvβ8, kunye ne-αvβ8, kunye ne-αvβ8. I-GLPG0187 yi-inhibitor enamandla ye-osteoclastic bone resorption kunye ne-angiogenesis. Unyango nge-GLPG0187 idosi-ngokuxhomekeka kwandisa i-E-cadherin/vimentin ratio, inika iiseli i-epithelial, i-sessile phenotype. I-GLPG0187 idosi-ngokuxhomekeka inciphisa ubungakanani be-aldehyde dehydrogenase ephezulu ye-prostate cancer cell [1]. Iziphumo zonyango ze-GLPG0187 ekujikelezeni kweeseli kunye ne-clumping. I-GLPG0187 ibonisa ukuncitshiswa okubalulekileyo okuxhomekeke kwithamo kwi-tumor cell migration. I-GLPG0187 kuzo zonke izigxininiso kunciphisa kakhulu ukwanda kweeseli[2].
Ekujoliswe kuko: αvβ1
